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Dec-23-2011 11:13printcomments

Marijuana: Mechanism of Action: Action on the CB-1 Receptor

It wasn’t until about 1965 that Mechoulum in Israel discovered the main ingredient and most of the interspersed mechanisms of action.

CB-1 receptors
CB-1 receptors. Photo courtesy:

(MOLALLA, Ore.) - On Dec. 12th I posted PTSD: Medical Marijuana Clinical Studies Confirm Benefits. The Clinical Studies were done in Israel and possibly are the first clinically controlled reports. Their studies were directed at the action of Cannabis on adverse memory problems which is the essence of PTSD. Their conclusion was that the beneficial action for adverse memory amelioration was action on CB-1 receptors. Along with this assertion was the statement that the brain was replete with CB-1 receptors all over. From a philosophical point of view, I AM a Doctor of Philosophy in Pharmacology, I decided to jump into this mélange with all four feet.

      Granny Storm Crows original list printed in in 2007 under the title, Medical Marijuana Use enumerates 55 medical conditions helped by Cannabis. In this list are 27 conditions related to the brain or the CNS. These are: anti-anguish, addiction therapy, alcoholism, ALS, alzheimers, anxiolytic, appetite stimulant, anti-autism, anti-psychotic, anti-huntingtons, anti-nauseant, anti-morning sickness, anti-depressant, anti-dystonia, anti-epileptic, ADD/ADHD, anti-mad cow disease, anti-migraines, anti-multiple sclerosis, anti-neurotic pain, neuroprotectant, anti-obsessive-compulsive disorder, analgesic, anti-spastic, anti-parkinsonism, anti-PTSD, anti-schizophrenic, anti-psychotic, sedative-hypnotic, anti-stroke, anti-spastic, anti-tourettes and probably a few more. Granny Storm Crows list is now more than 400 pages on her website.

      With this list of CNS conditions it must mean that there are multiple CB-1 sites each one or several providing relief of the conditions mentioned above. Presumably we know that the CB-2 receptors are in the periphery. I am not going into that. The CNS problems are probably more than I can understand. After all, Cannabis has been used successfully as medicine for at least 4000 years and it was thought it was one substance but it wasn’t until about 1965 that Mechoulum in Israel discovered the main ingredient and most of the interspersed mechanisms of action.

      If I am incorrect about my own philosophy and assertions, I hope somebody, somewhere will put me out of my misery. 



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Ricy Mardona September 17, 2012 9:29 pm (Pacific time)

thnks for the information...m looking for this..really like your blog

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